Você está aqui: Página Inicial > Mestrado > Mestrado em Biociências > English > Disciplines
conteúdo

Disciplines

publicado 05/10/2018 18h14, última modificação 10/08/2021 11h20
Syllabus of the disciplines of the Graduate Program in Biosciences (PPG-BC)

Mandatory disciplines
  

Biosafety and bioethics
Professor(s): Dr. Cristian Antonio Rojas, Dra. Danúbia Frasson Furtado and Dra. Rafaella Costa Bonugli Santos
Syllabus: Brazilian laws in biosafety, sources of information in biosafety, biosafety in research laboratories, biosafety in microbiological research; biosafety in research in animals, concepts in ethics and bioethics, national and international regulations regarding bioethics in scientific research, frauds and plagiarism in scientific research, ethics committees for research in humans and animals. 
Credit hours: 30 (thirty) class hours
Credits: 02 (two)
Bibliography:
BRASIL. Ministério da Saúde. Fundação Nacional de Saúde (FUNASA). Biossegurança em laboratórios biomédicos e de microbiologia. Brasília. 2001.
CIENFUEGOS, F. Segurança no Laboratório. Interciência, Rio de Janeiro. 2001.
HIRATA, MH, FILHO, JM. Manual de biossegurança. Editora Manole, São Paulo. 2001.
MASTROENI, MF. Biossegurança aplicada a laboratórios e serviços de saúde. Atheneu, Rio de Janeiro. 2004.
TEIXEIRA P, VALLE S. Biossegurança. Uma abordagem multidisciplinar. Editora Fiocrus, Rio de Janeiro, RJ, 2010.
MASTROENI, MF. Biossegurança Aplicada a Laboratórios e Serviços de Saúde. Ed. Atheneu, 2006, 334 pp.
DURAND, G. Introdução geral à bioética: história, conceitos e instrumentos. São Paulo: Loyola, 2003.
SEGRE, M.; COHEN, C. Bioética. 3. ed. São Paulo, Edusp. 2003.
FEIJÓ A.G. S. Animais na pesquisa e ensino: aspectos éticos e técnicos. EdiPUCRS, 2010, 421pp.
MARTINS, C. Tópicos de Bioética. DPL Editora, 2001 86pp. 13- Dall’Agnol. Bioética. Zahar Ed., 2005.

 

Statistics applied to biosciences
Professor(s): Dr. Thiago Luis de Andrade Barbosa
Syllabus: Basic concepts in statistics. Presentation of statistical data: series and charts. Descriptive measures. Probability. Probability Distribution. Sampling. Probability Distribution. Hypothesis test: Type I and II Error. Linear Regression Correlation. Variance analysis. Multivariate Analysis.
Credit hours: 45 (forty-five) class hours 
Credits: 03 (three)
Bibliography:
ARANGO, H.G. Bioestatística: teórica e computacional. 3 Ed. Rio de Janeiro: Ed. Guanabara Koogan, 2009.
BERQUÓ, E.S., SOUZA, J.M.P., GOTLIEB, S.L.D. Bioestatística. 2 ed. rev. São Paulo: Ed. Pedagógica e Universitaria Ltda, 2006.
CALLEGARI-JACQUES, S.M. Bioestatística: princípios e aplicações. Ed São Paulo: Artmed, 2006.
MORETTIN L.G. Estatística Básica – Probabilidade e Inferência. Pearson. São Paulo, 2010.
VIEIRA, S. Introdução à Bioestatística. 4 ed. Rio de Janeiro: Elsevier, 2008.
VIEIRA, S. Bioestatística: Tópicos Avançados. 3 ed. Rio de Janeiro: Elsevier, 2010.

 

Scientific method and scientific paper writing
Professor(s): Dra. Maria Claudia Gross, Dr. Carlos Henrique Schneider and Dr. Rodrigo Pinheiro Araldi
Syllabus: Scientific thinking. Research as an instrument of intervention in reality. Research outline. Guidelines for research planning. General steps of the scientific research. Ethics in research with human beings and in experimental research. Scientific writing. Reference management. 
Credit hours: 45 (forty-five) class hours
Credits: 03 (three)
Bibliography:
BELL, J. Projeto de pesquisa: guia para pesquisadores iniciantes em educação, saúde e ciências sociais. 4. ed. Porto Alegre: Artmed, 2008.
GALVÃO, C. M.; SAWADA, N.O.; TREVIZAN, M. A. Revisão Sistemática: recurso que proporciona a incorporação das evidências na prática da Enfermagem. Rev. Latino-am Enfermagem, v.12, n.3, p. 549-56.
HULLEY, S.B. et al. Delineando a pesquisa clínica: uma abordagem epidemiológica. 3. ed. Porto Alegre: Artmed, 2008.
KÖCHE, J.C. Fundamentos de metodologia científica – teoria da ciência e prática de pesquisa. 17ª ed. Petrópolis, Vozes, 2001. p.23-88.
LINCOLN YS, GUBA EG. Controvérsias paradigmáticas, contradições e
confluênciasemergentes. In: LINCOLN YS. O planejamento da pesquisa qualitativa: teorias e abordagens. 2ª Ed. Porto Alegre: Artmed, 2006.
MINAYO, MC de S. O desafio do conhecimento: pesquisa qualitativa em saúde. 12ª ed. São Paulo: Hucitec, 2010. p. 81-142.
PADILHA, M. I. C. S.; RAMOS, F. R. S.; BORENSTEIN, M. S.; MARTINS, C.R. A responsabilidade do Pesquisador ou sobre o que dizemos acerca da ética em pesquisa. Texto Contexto Enferm, v.14, n.1, p.96-105.

 

Research seminars
Professor(s): Dr. Francisney Pinto do Nascimento, Dr. Flávio Luiz Tavares, Dr. Jorge Luis Maria Ruiz, Dr. Kelvinson Fernandes Viana, Dr. Cristian Antonio Rojas, Dra. Carla Vermeulen Carvalho Grade, Dr. Gleisson Alisson Pereira de Brito, Dr. Pablo Henrique Nunes, Dra. Maria Claudia Gross, Dr. Carlos Henrique Schneider
Syllabus: Provide students with means to keep updated and develop a critical spirit in analyzing recent works described in literature through studies of scientific papers or reviews, group discussions and seminars about themes regarding the field of concentration. It will be developed in two strands: - Advanced topics in biosciences and health lectured by research professors and students in the different lines of research involved in the graduate program and out of it, emphasizing the theoretical-methodological aspects of their work. Presentation of the thesis plans and advancements in research produced by master’s degree students during the period of studies.
Credit hours: 30 (thirty) class hours
Credits: 02 (two)
Bibliography:
DAVIS, M. Scientific papers and presentations. San Diego: Academic Press, 1996.
MIN, L.S. Como ter acesso à literatura médica. In: Medicina baseada em evidências. DRUMMOND, J. P.; SILVA, E. São Paulo: Atheneu, 1999. p. 61-88.
SACKETT, D.L. et al. Medicina baseada em evidências: prática e ensino. Porto Alegre: Artmed, 2003.
Artigos científicos publicados em Revistas Nacionais e Internacionais dentro das áreas de concentração do curso.
 
 

Elective disciplines
  

Neurobiological and clinical basis for pain and nociception
Professor(s): Dr. Francisney Pinto do Nascimento
Syllabus: Terms and definitions of pain, nociceptors, nociceptive transmission, pain mediators, ascending pathways of pain, the spinal cord and pain, the neurobiology of chronic pain, animal models of pain, mediation of pain in humans, opioid pharmacology for pain, serotonin pharmacology for pain, non-steroidal anti-inflammatory drugs and pain, antidepressants, anticonvulsants, local anesthetics, antiarrhythmic drugs and calcium channel blockers and chronic pain, multidisciplinary approach to acute and chronic pain management, palliative care and pain, surgical treatment for chronic pain.
Credit hours: 45 (forty-five) class hours
Credits: 03 (three)
Bibliography:
HUNT SP, MANTYH PW. The molecular dynamics of pain control. Nature Reviews Neuroscience (2) 83-91, 2001.
JULIUS D, BASBAUM AI. Molecular mechanims of nociception. Nature (413) 203-210, 2001.
LE BARS D, GOZARIU M, CADDEN SW. Animal models of pain. Pharmacological Reviews (53) 597-652, 2001.
MELZACK R. Evolution of the neuromatrix theory of pain. World Institute of Pain, (5) 85-94, 2005.
PERL ER. Ideas about pain, a historical view. Nature Reviews Neuroscience (8) 71-80, 2007.
MCMAHON SB, KOLTZENBURG M. Wall & Melzack’s Textbook of Pain, 5th ed. Elsevier, Rio de Janeiro, 2012.
HOLDCROFT A, JAGGAR S. Core topics in pain. Cambridge, UK: Cambridge University Press, 2005.
LOZANO AM, GILDENBERG PL, Tasker RR. Textbook of stereotactic and functional neurosurgery, 2nd ed. Berlin: Springer, 2009.
CUKIERT A. Functional neurosurgery. São Paulo: Alaúde, 2014.
BEAULIEU, P, LUSSIER, D, PORRECA, F, DICKENSON, A. Pharmacology of Pain. Seattle, IASP, 2010.

 

Developmental biology and embryotoxicity
Professor(s): Dra. Carla Vermeulen Carvalho Grade
Syllabus: From embryology to developmental biology. Fertilization and egg metabolic activation. Development models. Fate maps. Embryonic induction mechanisms, organizers and signaling molecules. Cell and molecular principles of differentiation during morphogenesis and organogenesis. Normal and abnormal development of organic systems derived from embryonic leaflets. Fetal membranes and placenta. Current themes in human embryology. Critical period of embryonic development. Maternal/reproductive toxicity. Teratogenesis and toxicity.
Credit hours: 45 (forty-five) class hours
Credits: 03 (three)
Bibliography:
HOOD, R.D. Developmental and Reproductive Toxicology: A Practical Approach. Third Edition. New York: CRC Press, 2011.
GILBERT, S.F. Biologia do desenvolvimento. FUNPEC Editora, 2013.
GILBERT, S.F. Developmental biology. New York: Sinauer Associates, Inc, 2010.
MOORE, K.L.; PERSAUD, T.V.N. Embriologia básica. 8ª ed. Rio de Janeiro: Elsevier, 2013.
SADLER, T.W. Langman Embriologia Médica. 12ª ed. São Paulo: Guanabara Koogan, 2013.
SCHOENWOLF, G.C. et al. Embriologia Humana. 4ª ed. Rio de Janeiro: Elsevier, 2009.
WOLPERT, L.R. et al. Princípios de biologia do desenvolvimento. Porto Alegre: Artmed, 2000.

 

Molecular biology and gene regulation in cancer
Professor(s): Dr. Rodrigo Pinheiro Araldi
Syllabus: Molecular mechanisms which govern genetic regulation during carcinogenesis. Microevolution scenario. Methods for the investigation and identification of markers in each of the stages of the oncogenic process (initiation, promotion/progression and metastization). Introduction to oncology and global epidemiology of cancer. Chromatin structure, genetic structure and DNA replication. Eukaryotic transcription and transcriptional regulation mechanisms. Translation and post-translational regulation mechanisms. Initiation of neoplasia, mutations and mutagenesis. Cancer promotion and progression: cell cycle study methods. Epithelial-mesenchymal transition, cancer stem cells and metastasis. Identification methods of differentially expressed genes/proteins (PCR Array, Microarray, qRT-PCR, PCR digital, Proteome Profiler, CRISPR/Cas9, immunohistochemistry).
Credit hours: 45 (forty-five) class hours
Credits: 03 (three)
Bibliography:
ARALDI, R. et al. Genetics and metabolic deregulation following cancer initiation: A world to explore. Biomedicine & Pharmacotherapy, v. 82, p. 449–458, 2016. 
ABBAS, AK; LICHTMAN, AH; PILLAI, S. Imunologia Celular e Molecular, 7 edicao, ed Saunders Elsevier, p. 592, 2011
CAIRNS, R. A; HARRIS, I. S.; MAK, T. W. Regulation of cancer cell metabolism. Nature reviews. Cancer, v. 11, n. 2, p. 85–95, fev. 2011. 
CHABNER, BA; LONGO, DL. Manual de Oncologia de Harrison, 2 edição, Editora Artmed, p. 874, 2015
COLOTTA, F. et al. Cancer-related inflammation, the seventh hallmark of cancer: links to genetic instability. Carcinogenesis, v. 30, n. 7, p. 1073–81, jul. 2009. 
DE-SÁ-JÚNIO, P. et al. The roles of ROS in cancer heterogeneity and therapy. Oxidative Medicine and Cellular Longevity, 2017.
HANAHAN, D.; WEINBERG, R. Hallmarks of cancer: the next generation. Cell, v. 144, n. 5, p. 646–74, 4 mar. 2011. 
KASPER et al. Manual de Medicina de Harrison, 19 edição, Editora Artmed p. 1388, 2017
MARQUES, MV. Biologia Molecular e Genética Bacteriana, Ed. Sociedade Brasileira de Genética, p. 348, 2012
NELSON, DL; COX, MM. Princípios de Bioquímica de Lehninger, 5 edição, Editora Artmed, p. 1274, 2013
SINGH, A.; SETTLEMAN, J. EMT, cancer stem cells and drug resistance: an emerging axis of evil in the war on cancer. Oncogene, v. 29, n. 34, p. 4741–4751, 2010. 
WARBURG, O. On the origin of cancer cells. Science, v. 123, n. 3191, p. 309–14, 1953. 
WATSON, JD et al. Biologia Molecular do Gene, 7 edição, Editora Artmed, p. 878, 2015

 

Microbial bioprospecting applied to health
Professor(s): Dr. Michel Rodrigo Zambrano Passarini and Dra. Rafaella Costa Bonugli Santos
Syllabus: The discipline is developed through a theoretical and practical approach aiming at microbiological methods for the recovery of the microbial community in environmental samples through methods which depend on the cultivation and construction of Metagenomic libraries (cultivation independent methods) with the objective of searching for pharmacologically active compounds from microbial origins and their application to human and veterinary medicine, such as antibiotics, antitumor compounds, anti-inflammatory drugs and others. Bioessays for the activity detection. Microbial preservation and collections. Using microorganisms and bioreactors.
Credit hours: 45 (forty-five) class hours
Credits: 03 (three)
Bibliography:
VISE, J.C. Molecular markers, natural history, and evolution. 2ed. Sunderland: Sinauer, 2004.
LINCOLN, R. J. 2009. Diccionario de ecología, evolución y taxonomía 2ª Ed. Fondo de cultura económica.
MADSEN, E.L. 2008. Environmental Microbiology: From Genomes to Biogeochemistry. United Kingdom. Wiley-Blackwell. ISBN: 9781405136471.
MADIGAN, M.T.; MARTINKO, J.M.; DUNLAP, P.V. & D. P. Clark. 2010. Microbiologia de Brock. 12ed. Porto Alegre. Artmed. ISBN: 9788536320939.
HABNER, B.A.; KNOLLAMANN, C.C. GOODMAN. As Bases Farmacológicas da Terapêutica, 12ª ed. Mc Graw Hill, 2012.
PEPPER I.L, GERBA C.P. Environmental Microbiology A Laboratory Manual SECOND EDITION: 2004.
WALSH, G. BIOPHARMACEUTICALS BIOCHEMISTRY AND BIOTECHNOLOGY. Second Edition. Industrial Biochemistry Programme CES Department University of Limerick, Ireland, 2006.

 

Biochemistry and molecular genetics of microorganisms
Professor(s): Dr. Michel Rodrigo Zambrano Passarini and Dra. Rafaella Costa Bonugli Santos
Syllabus: Promote the knowledge of how microbial cell systems are structured and how they function, including genetic and biochemical conceptions, specially microbial metabolism inside the different groups, such as, the application of cultivation techniques, biochemical and genetic studies of important microorganisms to different areas of bioscience, because microorganisms, particularly bacteria and yeast, are model organisms which are widely used for experimental research.
Credit hours: 45 (forty-five) class hours
Credits: 03 (three)
Bibliography:
Hayden, R.T.; Belku, A.V. 2011. Molecular Microbiology: Diagnostic Principles and Practice. 2ed. ASM Press. ISBN-10: 1555814972.
Krebs, J.E.; Goldstein, E.G.; Kilpatrick, S.T. Lewin's GENES X. 2009. 10ed. Jones & Bartlett Learning. ISBN-10: 0763766321.
Madigan, M.T.; Martinko, J.M.; Dunlap, P.V. & D. P. Clark. 2010. Microbiologia de Brock. 12ed. Porto Alegre. Artmed. ISBN: 9788536320939.
Nascimento A.C.; Espreafico, E.M.; Larson, M.L.P.; Monesi M.; Rossi, N.M.M.; Rodrigues, V. 2003. Tecnologia do DNA Recombinante. Universidade de São Paulo, 86p.
Ninfa, A.J.; Ballou D.P & Benore, M. Fundamental Laboratory Approaches for Biochemistry and Biotechnology, 2nd Edition, 2009.
Persing, D.H.; Tenover, F.C; Tang, I-W.; Nolte, F.S.; Torotora, G.T.; Funke, B.R.; Case, C.L. Microbiologia, Artmed, Porto Alegre, 2000.
Trabulsi, L.R., Alterthum, F. Microbiologia. 5ª. ed., Ed. Atheneu, 2008

 

Biotoxinology: tools for biomedical research and its importance in health
Professor(s): Dr. Flávio Luiz Tavares and Dra. María Elisa Peichoto
Syllabus: General aspects of accidents with poisonous animals: global eco-epidemiological panorama and in the Three-Border Region. Physiopathological fundamentals, diagnosis, therapeutic approach and prevention of snake, spider and worm poisoning. Scientific research in Biotoxinology and its deployments in the biomedical field.
Credit hours: 45 (forty-five) class hours
Credits: 03 (three)
Bibliography:
WEN, F.H.; FRANÇA, O.S.F.; CARDOSO, J.L.C. Animais Peçonhentos no Brasil - 2ª Ed. – São Paulo, Ed. Sarvier. 2010.
PEICHOTO, M.E.; SALOMÓN, O.D. La problemática del ofidismo en la región Nordeste de Argentina. Instituto Nacional de Medicina Tropical: Puerto Iguazú, Argentina, 2014.
MACKESSY, S.P. Handbook of Venoms and Toxins of Reptiles. First Edition. CRC Press, 2009.
FRY, B.G. Venomous Reptiles and Their Toxins: Evolution, Pathophysiology and Biodiscovery. First Edition. Oxford University Press. 2015.
SPINOSA, H. S.; GORNIAK, S.L.; PALERMO-NETO, J. Toxicologia Aplicada à Medicina Veterinária. 1a ed. São Paulo, ed. Manole. 2008.
OGA, S.; CAMARGO, M. M. A.; BATISTUTO, J.A.O. Fundamentos de Toxicologia. 3a. ed. São Paulo: Atheneu, 2008.
RANG, H. P.; DALE, M.M., FLOWER, R. J.; RITTER, J. M.; HENDERSON, G. RANG & DALE. Farmacologia. 8a ed., Rio de Janeiro, Guanabara Koogan, 2016.

 

Medical cannabinology
Professor(s): Dr. Francisney Pinto do Nascimento
Syllabus: The historical and traditional use of Cannabis, history of the scientific route of the cannabinoid system, Cannabis in the war against drugs, prohibition and regulation of Cannabis, chemistry of Cannabis, cannabinoid receptors, enzymes of the cannabinoid system, neurotransmitters which affect the cannabinoid system, endogenous cannabinoids, cannabinoids as therapeutic tools, actions and potentials of cannabinoids as pain, parkinson, epilepsy, depression, alzheimer, cancer, gastrointestinal disorder treatment and others. 
Credit hours: 45 (forty-five) class hours
Credits: 03 (three)
Bibliography:
BONFA, L., et al. Cannabinoids in chronic pain and palliative care. Ver. Bras. Anestesiol. v.58, n.3, p.267-279, 2008
BRUCKI, S.M.D., et al. Cannabinoids in Neurology – Brazilian Academy of Neurology. Arq. Neuro-Psiquiatr. v.73, n.4, 2015
BURGIEMAN, DR. O fim da Guerra: A maconha e a criação de um novo sistema para lidar com as drogas. Leya, São Paulo, 2011.
FOX, S.H., et al. Stimulation of Cannabinoid Receptors Reduces Levodopa-Induced Dyskinesia in the MPTP-Lesioned Nonhuman Primate Model of Parkinson’s Disease. Mov. Disord. v.17, n.6, p.1180-1187, 2002
GONZALEZ, B., et al. Cannabinoid Agonists Stimulate [3H]GABA Release in the Globus Pallidus of the Rat When Gi Protein-Receptor Coupling Is Restricted: Role of Dopamine D2 Receptors. J. Parmacol. Exp. Ther. v.328, n.3, p.822-828, 2009
MECHOULAM, R., et al. Identification of an endogenous 2-monoglyceride, present in canine gut, that binds to cannabinoid receptors. Biochem. Pharmacol. v.50, n.1, p.83- 90, 1995
PAMPLONA, F.A, TAKAHASHI, R.N. Psychopharmacology of the endocannabinoids: far beyond anandamide. J Psychopharmacol. v.26, n.1, p.7-22, 2012
PIOMELLI, D. The molecular logic of endocannabinoid signalling. Nat Rev Neurosci. v.4, n.11, p.873-884, 2003
PORRAS, F.E., et al. Motor effects of the non-psychotropic phytocannabinoid cannabidiol that are mediated by 5-HT1A receptors. Neuropharmacology. v.75, p.155-163, 2013
RUIZ, J.F, et al. Cannabidiol for neurodegenerative disorders: important new clinical applications for this phytocannabinoid? Br J Clin Pharmacol. v.75, n.2, p.323-333, 2012
SAITO, V. M. Exploração farmacológica do sistema endocanabinoide: novas perspectivas para o tratamento de transtornos de ansiedade e depressão?. Rev. Bras. Psiquiat. v.32, n.1, 2010
SAVAGE SR, ROMERO-SANDOVAL A, SCHATMAN M, WALLACE M, FANCIULLO G, MCCARBERG B, WARE MA. Cannabis in pain treatment: clinical and research considerations.
SIERADZAN, K.A., et al. Cannabinoids reduce levodopa-induced dyskinesia in Parkinson’s disease: A pilot study. Neurol. v.57, p.2108-2111, 2001
WARE MA, MARTEL MO, JOVEY R, LYNCH ME, SINGER J. A prospective observational study of problematic oral cannabinoid use. Psychopharmacology (Berl). 2018 Feb;235(2):409-417.
ZANELATI, T.V. Antidepressant-like effects of cannabidiol in mice: possible involvement of 5-HT1A receptors. Br J Pharmacol. v.159, n.1, p.122-128,2010.

 

Human chronobiology
Professor(s): Dr. Felipe Beijamini
Syllabus: Time and biological time; Endogeneity of biological rhythms; Synchronization mechanisms, entrainment and internal temporal order; Chronobiology, homeostasis and rheostasis; Evolution of biological rhythmicity and molecular control mechanisms of biological rhythmicity; Wake-sleep cycle and its mechanisms of regulation; Biological rhythmicity and social organization; Chronobiology study methods and techniques.
Credit hours: 45 (forty-five) class hours
Credits: 03 (three)
Bibliography:
MARQUES N., & MENNA-BARRETO, L. Cronobiologia: princípios e aplicações. Edusp. 1997. ISBN 85-314-0400-2.

 

Scientific dissemination
Professor(s): Dr. Francisney Pinto do Nascimento
Syllabus: History and impact of scientific dissemination, dissemination as scientific accountability, strategies for making science popular, types and tools of scientific dissemination, scientific dissemination in social media, the event named ‘Pint of Science’, the impact of scientific dissemination in society and in obtaining financial resources for science, the relationship between scientists and the media, interviews with scientists.
Credit hours: 45 (forty-five) class hours
Credits: 03 (three)
Bibliography:
AFONSO, EGM. A divulgação científica para o grande público: o papel das Relações Públicas. Dissertação de mestrado em Ciências da Comunicação, Universidade Fernando Pessoa, Porto, Portugal, 2008.
DESAI, PS. Marketing and Science. Marketing Science, vol 30, N1, 1-3. 2011.
EUROPEAN COMISSION. Scienti research and the media. Eurobarometer report. Londres, 2015.
FLORES, GB. Entre a ciência e a mídia: um olhar da assessoria de imprensa. Dissertação de Mestrado em Ciências da Linguagem, UNISUL, SC, 2005.
FUNDORA, YS; GARCÍA, YR. La divulgación científica: una herramienta eficaz en centros de investigación. Resenas y reflexiones, ano 7, N7, 91-94, La Habana, 2011.
MACHADO, FS. Scientific divulgation and Digital utterances. Bakhtiniana, São Paulo, 11 (2): 101-118, May/Aug. 2016.
SANDFORD, SA; DWORKIN, JP; BERNSTEIN MP. A template for scientific press releases and science news articles. Annals of improbable research, 12-14, july 2004. 

 

Entrepreneurship for scientists
Professor(s): Dr. Fabrício Alano Pamplona
Syllabus: Professional self knowledge. How to connect what I know how to do and what I like to what the work market values. Discussions and conceptions of professional development, career, employability and entrepreneurship. The future of the job. Traditional careers versus non linear careers. New types of organizations. How to identify a value proposition that makes sense. The development of businesses in an experimental approach (leanstartup). Testing hypothesis of businesses. Learning how to learn in entrepreneurship. Metrics and experiments. Practical exercise of career prototyping. Practical exercise of business prototyping. Fundamentals of potential evaluation of a new company. Business development focused on the client.
Credit hours: 30 (thirty) class hours
Credits: 02 (two)
Bibliography:
Business Model You - Alexander Ostwerwalder e Yves Pigneur A. Altabooks, São Paulo, 2016.
A Startup Enxuta - Eric Reis, Crown Publishing Group, Nova York, 2011.
Estilo Startup: Como empresas modernas usam o empreedendedorismo para se transformar e crescer - Eric Reis. Editora Leya, Lisboa. 2014.
Startup: Manual do Empreendedor - Steven Blank. Altabooks editora, São Paulo, 2015.
Do Sonho à Realização em 4 passos - Steven Blank. Editora Évora, São Paulo, 2012.
Organizações Exponenciais - Salim Ismail, Michael Malone, Yuri van Geest, Peter Diamandis. Altabooks Editora, São Paulo, 2013. 

 

Genetic engineering
Professor(s): Dr. Cristian Antonio Rojas
Syllabus: Technical possibilities of editing prokaryotic and eukaryotic genomes with examples of biotechnological application in plants, animals, fungus and bacteria. 
Credit hours: 30 (thirty) class hours
Credits: 02 (two)
Bibliography:
MACHIDA, CURTIS A. VIRAL VECTORS FOR GENE THERAPY. Ed. 1. HUMANA PRESS, 2002.
TOMA, H. E. Nanotecnologia Molecular - Materiais e Dispositivos. Coleção de Química Conceitual. Blucher, V. 6, 2016.
Genome Editing. Editors: Turksen, Kursad (Ed.). SPRINGER, 2016.
Biotechnology of Plant Secondary Metabolism. Methods and Protocols. Editors: Fett-Neto, Arthur Germano (Ed.). SPRINGER. 2016.
CRISPR-Cas: A Laboratory Manual. Edited by Jennifer Doudna and Prashant Mali. COLD SPRING HARBOR LABORATORY PRESS. 2016.

 

Evolution and human health 
Professor(s): Dr. Gleisson Alisson Pereira de Brito
Syllabus: Study about human health from an evolutionary biology perspective. Principles of evolution. Evolution of hominids. Biological and social cultural human adaptations to environmental challenges. Proximate and ultimate causes: evolutionary hypothesis of human health. Human biological variability and health. Darwinian medicine.
Credit hours: 45 (forty-five) class hours
Credits: 03 (three)
Bibliography:
DIAMOND, J. Armas, germes e aço. 14 ed. Rio de Janeiro, 2012.
FREEMAN, S.; HERRON, J.C. Análise evolutiva. Porto Alegre: Artmed, 2009.
KORMONDY, E.J.; BROWN, E. D. Ecologia humana. Rio de Janeiro: Atheneu, 2013.
MORAN, E.F. Adaptabilidade humana. Edusp, 2010.
LEWIN, R.; FOLEY, R. Principles of human evolution. 2 ed. New York: Wiley-Blackwell, 2013.
LIEBERMAN, D. The story of the human body: evolution, health, and disease. New York: Vintage, 2013.
STANFORD, C. et al. Biological anthropology. 3ed. New York: Pearson, 2011. 

 

Human and clinical genetics ​
Professor(s): Dra. Maria Leandra Terencio and Dr. Carlos Henrique Schneider
Syllabus: Organization of the human genome; Genes and diseases; Chromosomes and chromosomal anomalies with an epidemiological focus. Genetic mechanisms and pathological conditions. Multi-factor disorders and complex diseases. Molecular techniques for investigating and diagnosing complex diseases; Cytogenetic techniques for investigating and diagnosing chromosome diseases and cancer.
Credit hours: 45 (forty-five) class hours
Credits: 03 (three)
Bibliography:
CALLEGARI-JACQUES, S.M. et al. Historical genetics: spatiotemporal analysis of the formation of the Brazilian population. Am J Hum Biol., v.15, p.824-834, 2003.
DUNHAM, I. et al. An integrated encyclopedia of DNA elements in the human genome. Nature, v. 489, p.57-64, 2012.
GLICK, B.R.; PASTERMAK, J.J. Molecular biotechnology: principles and applications of recombinant DNA. 4ed. Washington: ASM Press, 2009.
GODINHO, N.M.O. et al. Regional patterns of genetic admixture in South America. Forensic Science International: Genetics Supplement Series, v.1, p.329-330, 2008.
LODISH, H. et al. Molecular cell biology. 4th ed. New York: W. H. Freeman & C o, 2008.
MALUF, S.W. et al. Citogenética Humana. Porto Alegre: Ed. Artmed S.A., 2011.
PENA S.D. et al. The genomic ancestry of individuals from different geographical regions of Brazil is more uniform than expected. PLOS ONE, v.6: e17063, 2011.
PINKEL, D.; STRAUME, T.; GRAY, J.W. Cytogenetic analysis using quantitative, high-sensitivity, fluorescence hybridization. Proceedings of the Natural Academy of Science, v.83, p.2934-2938, 1986.
READ, A.; DONNAI, D. New clinical genetics. 3 ed. New York, 2015.
SAMBROOK, J.; RUSSELL, D.W. Molecular cloning: a laboratory manual. New York: Cold Spring Harbor Press. Cold Spring Harbor, 2011. Volume 1.

 

Integrative genetics: from the dna to the chromosome, going through their alterations
Professor(s): Dra. Maria Claudia Gross and Dra. Maria Leandra Terencio
Syllabus: DNA and RNA: structure, chemical composition and functions. Genome organization and composition; nuclear and mitochondrial DNA. Molecular markers and their application. Cloning and its application. DNA sequencing: from Sanger to NGS. Chromosome preparation and chromosome physical mapping of sequences of interest. Genetic biomarkers for environmental monitoring: chromosome aberrations, micronuclei frequency and erythrocytic nuclear alterations, comet assay.
Credit hours: 45 (forty-five) class hours
Credits: 03 (three)
Bibliography:
BENJAMIN L. 2009. Genes XII. ArtMed. BORÉM, A.; CAIXETA, E.T. 2009. Marcadoresmoleculares. 2ª Ed. Viçosa, 532p.
BROWN T. A. 2010. Gene Cloning And Dna Analysis. John Wiley Professional.
DAVID L. NELSON & Ferreira, M.E.; Grattapaglia, D. 1996. Introdução ao uso de marcadores moleculares em análise genética. 2ª Ed. Brasília: Embrapa/Cenargen, 220p.
GUERRA, M. 2012. Citogenética Molecular: protocolos comentados. Ribeirão Preto: Editora da Sociedade Brasileira de Genética, 172p.
LEWIS J., ALBERTS B., Bray D. 2009. Biologia Molecular da Célula. 5a ed. ArtesMédicas. 1463p
SNUSTAD, D.P.; SIMMONS, M.J. 2008.Fundamentos de Genética. 4ª Ed. Rio de Janeiro: Guanabara Koogan, 903p.
RIBEIRO, L. R.; SALVADORI, D. M. F.; MARQUES, E. K. Mutagêneseambiental. Ed. Ulbra, 1a Ed., 2003. 365 p. ISBN 85-7528-067-8.
SILVA, J. 2007. O uso do ensaiocometapara o ensino de genéticatoxicológica. Genéticanaescola: 2(2): 30- 33.
SOCIEDADE BRASILEIRA de MUTAGÊNESE, carcinogênese e teratogêneseambiental: http://www.sbmcta.org.br. 

 

Immunometabolism and chronic disease
Professor(s): Dr. Gleisson Alisson Pereira de Brito
Syllabus: Investigation of the interface between immunology and metabolism. Immunometabolic interplay mechanisms and their relation to the physiopathology of non-transmissible chronic diseases. Immunometabolic modulation through physical activity and nutrients.
Credit hours: 45 (forty-five) class hours
Credits: 03 (three)
Bibliography:
CAVA, L.A.; MATARESE, G. The weight of leptin in immunity. Nature Reviews, Immunology, v.4, p.371-379, 2004.
DELVES, P. J.; ROITT, I. M. Advances in Immunology. The immune system. First of Two Parts. The New England Journal of Medicine, v. 343, p.37 – 49, 2000.
DONATH, M.Y.; SHOELSON, S.E. Type 2 diabetes as an inflammatory disease. Nature, V.11, p. 98 – 107, 2011.
GLEESON, M. Immune function in sport and exercise. Philadelphia: Ed Elsevier, 2006.
HANSSON, G. K.; HERMANSSON, A. The immune system in atherosclerosis. Nature, v. 12, n.3, p 204 – 212, 2011.
HOTAMISLIGIL, G.S. Inflammation and metabolic disorders. Nature, v. 444 p. 860 – 867, 2006.
MATHIS, D.; SHOELSON, S.E. Immunometabolism: an emerging Frontier. Nature Reviews, Immunology, v. 11, p. 81 – 83, 2011.
ROITT, I. et al. Fundamentos de imunologia. 7ª ed. São Paulo: Artmed, 2010.
SHOELSON, S.E.; LEE, J.; ALLISON, B. Inflammation and insulin resistance. J Clin Invest, v.116, p.1793–1801, 2006.
WELLEN, K.E.; HOTAMISLIGIL, G.S. Inflammation, stress, and diabetes. J Clin Invest, v.115, p.1111–1119, 2005.

 

Immunoparasitology
Professor(s): Dr. Kelvinson Fernandes Viana
Syllabus: Parasite host relationship in the context of immunology, humoral and cellular alterations in parasitosis, immune response modulations with helminths and protozoa, immune alterations in vector transmitted parasitosis.
Credit hours: 30 (thirty) class hours
Credits: 02 (two)
Bibliography:
NEVES, D.P. Parasitologia Geral. 2012
ABBAS, A. Imunologia Celular e Molecular. 2012.

 

Analytical method for extracting organic compounds in complex matrices
Professor(s): Dra. Aline Theodoro Toci
Syllabus: Introduction to the preparation of samples; Classical or Conventional Techniques; Solid Phase Extraction Techniques: Solid phase extraction (SPE), Solid phase microextraction (SPME), Extraction with molecularly imprinted polymers; Miniaturizes Techniques: Dispersive liquid-liquid microextraction; Other techniques: Microwave-assisted extraction (MAE) and supercritical fluid extraction (SFE); Theories and applications.
Credit hours: 30 (thirty) class hours
Credits: 02 (two)
Basic Bibliography:
BORGES, K.B.; FIGUEIREDO, E.C.; QUEIROZ, M.E.C. Preparo de Amostras para análise de compostos orgânicos, 1 ed., LTC, 2015.
MITRA, S. Sample preparation in analytical chemistry. 1 ed.,  John Wiley & Sons Ltd, 2003.
MOLDOVEANU, S. & DAVID, V. Modern Sample Preparation for Chormatography. 1 ed, Elsevier, 2015.
KINGSTON, H.M. & HASWELL, S. J. Microwave-enhanced chemistry: fundamentals, sample preparation, and applications. 1 ed., American Chemical Society, 1997.

Complementary Bibliography:
DAVID, F. & SANDRA, P. Stir bar sorptive extraction for trace analysis (Review). Journal of Chromatography A, 1152 (2007) 54–69.
KATAOKA, H., LORD, H. L., PAWLISZYN, J. Applications of solid-phase microextraction in food analysis. Journal of Chromatography A, 880 (2000) 35–62.
SANZ, C.; ANSORENA,D.; BELLO, J.; CID, C. Optomizing Headspace Temperature and Time Sampling for Identification of Volatile Compounds in Ground Roasted Arábica Coffee. J. Agric.Food Chem., 49, 1464-1469, 2001.
SKOOG, D. A., HOLLER, F. J. CROUCH, S. R. Principles of Instrumental Analysis. 6 ed., Thomson Brooks/Cole, 2007.

 

Neurobiology of disorders of human behavior 
Professor(s): Dr. Seidel Guerra López
Syllabus: Basic neurobiology of human behavior. Brain and violence. Biological phases of violent behavior. Biological basis of addictive behaviors and their relations with social phenomena. Neurodevelopmental disorders and child violence. Specific and general learning disorders and their relation to irruptive behaviors in schools. Relations between parental neurobiology, child abuse and street children. Neurocognitive and motor impairment. Attention deficit and hyperactivity disorders. School failure, mental retardation and violent behaviors.
Credit hours: 45 (forty-five) class hours
Credits: 03 (three)
Bibliography:
BRUST, J.C. A prática da neurociência. Rio de Janeiro: Revinter: 2010.
ILLERIS, K. Teorias contemporâneas da aprendizagem. Porto Alegre: Penso Editora, 2013.
KANDEL, E.R. Princípios de neurociências. 5 ed. Mc Graw Hill, 2014.
PURVES, D. Neurocience. 5th ed. New York: Sinauer Associates Inc, 2012.
RODRIGUES, J.A.; RIBEIRO, M.R. Análise do comportamento. Pesquisa, teoria e aplicação. Porto Alegre: Artmed, 2005.
WRIGHT, J.H. Terapia cognitivo comportamental de alto rendimento para sessões breves. Porto Alegre: Artmed, 2012.
YUDOFSKY, S.C.; HALES, R. Fundamentos de neuropsiquiatria e ciências do comportamento. 2 ed. Porto Alegre: Artmed, 2014.

 

Cognitive neuroscience of learning and education
Professor(s): Dr. Francisney Pinto do Nascimento e Dr. Giuliano Emerenciano Ginani
Syllabus: Myths about neuroscience and learning, Methods of Cognitive Neuroscience, Neurophysiology of learning, Basic cognitive functions, Executive functions and neurodevelopment, Social cognition, Cognitive Chronobiology, Psychopharmacology of learning, Social and economic effects on neurodevelopment and cognition, Relationship between technology and brain function, Self-regulatory neuromodulation, Neural basis for learning disorders, Neuroscientific evidence-based education.
Credit hours: 45 (forty-five) class hours
Credits: 03 (three)
Bibliography:
BEAR, M. F.; CONNORS, B. W.; PARADISO, M. A. Neurociências: Desvendando o sistema nervoso. 3a ed. Porto Alegre: Artmed, 2008.
EYSENCK, Michael W.; KEANE, Mark t. Manual de Psicologia Cognitiva-7. Artmed Editora, 2017.
KANDEL, E. R, SCHWARTZ, J. H, JESSELL, T. M. Princípios de Neurociências, 5a ed, Porto Alegre, Artmed, 2014.
GAZZANIGA, M. The Cognitive Neurociences. 4th ed. New York: MIT Press, 2009.
GONÇALVES O. F., BOGGIO P. S. Neuromodulação autorregulatória: príncipios e prática. São Paulo: Casa do Psicólogo; 2006.
MALLOY-DINIZ, L. F, MATTOS, P.; ABREU, N.; FUENTES, D. (Org.). Neuropsicologia: aplicações clínicas. 1ed. Porto Alegre: Artmed, 2015.
Periódicos científicos (exemplos de periódicos científicos como fonte de trabalhos selecionados para apresentação oral): Brain, Brain and Cognition, Cognition, Frontiers in Psychology, Nature, Nature Neuroscience, NeuroImage, Journal of Cognitive Neuroscience, Neuropsychologia, Neuropsychopharmacology, Psychopharmacology.

 

Principles of neurosciences and physiopathology in the disorders of the central nervous system
Professor(s): Dr. Francisney Pinto do Nascimento and Dr. Seidel Guerra López
Syllabus: Neurons and glia, the action potential, synaptic transmission, neurotransmitter systems, the autonomic nervous system, the central nervous system, chemical control of the brain and behavior, biological mechanisms of emotions in the brain, memory and learning systems, physiopathology of epilepsy and schizophrenia, physiopathology of depression and anxiety, physiopathology of Parkinson and Alzheimer Disease.
Credit hours: 45 (forty-five) class hours
Credits: 03 (three)
Bibliography:
KANDEL, E. R, SCHWARTZ, J. H, JESSELL, T. M. Princípios de Neurociências, 5a ed, Porto Alegre, Artmed, 2014.
BEAR, M. F.; CONNORS, B. W.; PARADISO, M. A. Neurociências: Desvendando o sistema nervoso. 3a ed. Porto Alegre: Artmed, 2008.
CASTRO, F.S. Corpo, mente e cérebro na Antiguidade: um breve estudo histórico. Rio de Janeiro, 2009. Dissertação (mestrado em psicologia clínica) – Pontifícia Universidade Católica do Rio de Janeiro.
CLARK, D. A.; BECK, A. T. Terapia cognitiva para os transtornos de ansiedade. Porto Alegre: ARTMED, 2012.
LENT, R. (Coord.) Neurociência da mente e do comportamento. Rio de Janeiro: Guanabara Koogan, 2008.
Rodríguez-Nogales C, Garbayo E, Carmona-Abellán MM, Luquin MR, Blanco-Prieto MJ. Brain aging and Parkinson's disease: New therapeutic approaches using drug delivery systems. Maturitas. Feb; 84:25-31, 2016.
BONNET, A.E., MARCHALANT, Y. Potential Therapeutical Contributions of the Endocannabinoid System towards Aging and Alzheimer's Disease. Aging Dis. 2015 Oct 1;6(5):400-5.
Goldberg EM, Coulter DA. Mechanisms of epileptogenesis: a convergence on neural circuit dysfunction. Nat Rev Neurosci. 2013.
Prediger RD, Matheus FC, Schwarzbold ML, Lima MM, Vital MA. Anxiety in Parkinson's disease: a critical review of experimental and clinical studies. Neuropharmacology. 2012; 62(1):115-24.
Disner SG, Beevers CG, Haigh EA, Beck AT. Neural mechanisms of the cognitive model of depression. Nat Rev Neurosci. 2011 Jul 6;12(8):467-77.

 

Chemical prospection of secondary metabolites
Professor(s): Dra. Jociani Ascari
Syllabus: Origin of secondary plant metabolites. Classification of secondary metabolites. Extraction methods. Isolation and purification techniques. Principles of chromatography (planar, liquid and gas). Principles of hyphenated techniques. Principles of structural elucidation of organic compounds. Nuclear Magnetic Ressonance Mass Spectrometry.
Credit hours: 45 (forty-five) class hours
Credits: 03 (three)
Bibliography:
HANSON, J. R. Natural Products: the secondary metabolites. London: Royal Society of Chemistry, 2003.
COLLINS, C. H. et al. Fundamentos de Cromatografia. Campinas, SP: UNICAMP, 2006.
LANÇAS, F. M. Cromatografia líquida moderna: HPLC/CLAE. Campinas, SP: Átomo, 2009.
SILVERSTEIN, R. M.; WEBSTER, F. X.; KIEMLE, D. J. Spectrometric identification of organic compounds. 7th ed. Hoboken, N. J.: Wiley, 2005.

 

Systematic review in health
Professor(s): Dr. Francisney Pinto do Nascimento
Syllabus: Definition and application of systematic reviews. Levels of scientific evidence. Planning of systematic reviews and meta-analysis. Metabias and bias. Search strategies. Access to database. Protocol registering. Writing a systematic review. RevMan App.
Credit hours: 45 (forty-five) class hours
Credits: 03 (three)
Bibliography:
HIGGINS, J. P. T., GREEN S. Cochrane Handbook for Systematic Reviews of Interventions, The Cochrane Collaboration. 2011.
LIBERATI, A. "The PRISMA statement for reporting systematic reviews and meta-analyses of studies that evaluate health care interventions: explanation and elaboration." J Clin Epidemiol 62(10): e1-34. 2009.
SHAMSEER, L., et al. (2015). "Preferred reporting items for systematic review and meta-analysis protocols (PRISMA-P) 2015: elaboration and explanation." Bmj 349: g7647. de VRIES, R. B., et al. (2014). "The usefulness of systematic reviews of animal experiments for the design of preclinical and clinical studies." Ilar j 55(3): 427-437.
RITSKES-HOITINGA, M., et al. (2014). "Systematic reviews of preclinical animal studies can make significant contributions to health care and more transparent translational medicine." Cochrane Database Syst Rev 3: ED000078.
PETERS, J. L., et al. (2006). "A systematic review of systematic reviews and meta-analyses of animal experiments with guidelines for reporting." J Environ Sci Health B 41(7): 1245-1258.
de VRIES, R. B. M., et al. (2015). "A protocol format for the preparation, registration and publication of systematic reviews of animal intervention studies." Evidence- based Preclinical Medicine 2(1): 1-9.

 

Chromatography techniques for analysis
Professor(s): Dra. Aline Theodoro Toci
Syllabus: Historical development and current importance. Gas chromatography. High Performance Liquid Chromatography (HPLC). Chemical and physical principles of the techniques, instrumentation, detectors, mobile and stationary phases and applications. Qualitative and quantitative analysis. Experimental part.
Credit hours: 30 (thirty) class hours 
Credits: 02 (two)
Bibliography:
AQUINO NETO, F.R. & NUNES, D.S.S. Cromatografia: Princípios Básicos e Técnicas Afins, Rio de Janeiro: Interciência, 2003.
COLLINS, C. H et al. Fundamentos de Cromatografia. 1 ed. São Paulo: Unicamp, 2007.
HARRIS, D.C. Análise Química Qualitativa, Rio de Janeiro: LTC, 2005.
MILLER, J.M. & McNAIR, H.M. Basic Gas Chromatography. 2 ed. New Jersey: Wiley, 2009.
SKOOG, D. A. et al. Fundamentos de Análise Instrumental. 8. ed. São Paulo: Cengage Learning, 2006. 

 

Techniques for handling and using animals in biosciences
Professor(s): Dr. Francisney Pinto do Nascimento and Dr. Flávio Luiz Tavares
Syllabus: History of the use of animals in biomedical research, national and international laws about the use of animals in the laboratory, ethics in the use of animals for scientific research, handling of animals for scientific experimentation, management of animals in behavioral experimentation, techniques of drug administration routes in animals, techniques for collecting material from animals, analgesia and anesthesia in laboratory animals, handling of animals in invasive experiments, surgical techniques in animals, post surgery care for animals.
Credit hours: 45 (forty-five) class hours
Credits: 03 (three)
Bibliography:
ANDRADE, A.; PINTO, S.C.; OLIVEIRA, R.S. Animais de Laboratório Criação e Experimentação. Ed. FIOCRUZ, Rio de Janeiro, 2002.
ANDERSEN, M.L.; D’ALMEIDA, V.; KO, G.M.; KAWAKAMI, R.; MARTINS,P.J.F.; MAGALHÃES, L.E.; TUFIK, S. Princípios éticos e práticos do uso de animais de experimentação. São Paulo: UNIFESP – Universidade Federal de São Paulo, 2004.
BAKER, D.G. Natural pathogens of laboratory mice, rats, and rabbits na their effects on research. Clin Microbiol Rev, 1998, 11(2): 231.
GAILLLARD, E.T.; CLIFFORD, C.B. Common Diseases. In: ACADEMIC PRESS Rat Pathogens, USA, 2000.
WAGGIE, K.; KAGIYAMA, N.; ALLEN, A.M.; NOMURA, T. Manual Of Microbiologic Monitoring of Laboratory Animal. 2 ed. U.S. Departament Of Health And Human Services, National Institute of Health. 1994 (NIH Publication No. 94-2498).
CANADIAN COUNCIL ON ANIMAL CARE. Guide to Care and Use of Experimental Animals. CCAC, Ottawa, 2010.
MEZADRI, T.J. Animais de laboratório: cuidados na iniciação experimental. Ed. UFSC, Florianópolis, SC, 2004.
NATIONAL RESEARCH COUNCIL. Guide for the care and use of laboratory animal. National Academy of Sciences, Washington, DC. 2011.

 

Technology in vaccine development and production
Professor(s): Dr. Kelvinson Fernandes Viana
Syllabus: Principles of vaccinology, vaccine immunology, reverse vaccinology, types of vaccines, vaccine testing platforms, animal models for vaccine studies, systems for obtaining antigens and producing vaccines. 
Credit hours: 30 (thirty) class hours
Credits: 02 (two)
Bibliography:
PLOTKIN, S.; ORENTEIN, W.; OFFIT, P.; EDWARDS, K. M. Plotkins Vaccines, 7th edition, Elsevier, 2017.
ABBAS, A.K.; LICHTMAN, H. Imunologia Celular e Molecular, 7ª. ed. Rio de Janeiro: Elsevier, 2008.
MALAGUTTI, W. Imunização, Imunologia e Vacinas. São Paulo: Rubio, 2011.

 

Topics in regenerative medicine: gene and cell therapy
Professor(s): Dr. Jorge Luis Maria Ruiz
Syllabus: Definitions and characteristics of embryo, adult, mesenchymal and tumor stem cells. Stem cell niche. Introduction to gene therapy. Cloning and molecular tools. Cell reprogramming (iPS/RiPSC cells). Gene therapy in vivo and ex vivo. Therapeutic and biotechnological approaches using stem cells and gene therapy. 
Credit hours: 45 (forty-five) class hours
Credits: 03 (three)
Bibliography:
CHIU, Arlene; RAO, Mahendra S. Human Embryonic Stem Cells. Totowa NJ, USA: Human Press, 2003. 464 p.
SELL, Stewart. Stem Cell Handbook. Totowa NJ, USA: Human Press, 2003. 528 p. Advances in Cancer Stem Cell Biology. Scatena R, Mordente A, Giardina B (Eds). Springer, 2012.
Strachan T e Read, A. Human Molecular Genetics – Garland Science – New York – USA- 4th Edition
LATTIME, E, GERSON, S. Gene Therapy of Cancer. 3rd Edition, AP. 2013
HERZOG, RW. A guide for Human Gene Therapy. ISBN-13: 978-9814280907
Periódicos científicos (exemplos de periódicos científicos como fonte de trabalhos selecionados para apresentação oral): Cell, Gene Therapy, Human Gene Therapy, Molecular Therapy, Curr. Gene Therapy, J. of Gene Medicine, Cancer Gene Therapy, Cell, Nature Medicine, Nature Biotechnology, Science

 

Topics in cellular and molecular biology
Professor(s): Dra. Carla Vermeulen Carvalho Grade e Dr. Pablo Henrique Nunes
Syllabus: Study of nucleic acids; transcription and translation; gene regulation; study of techniques in molecular biology in the study of cells and mammal systems, including methods for obtaining and using transgenic animals, transfection methods in cell culture and analysis of gene expression. Basis of gene engineering: DNA cloning, DNA libraries, vectors and probes, DNA sequencing, PCR and electrophoresis.
Credit hours: 45 (forty-five) class hours
Credits: 03 (three)
Bibliography:
ALBERTS, B. et al. Molecular biology of the cell. 6th ed. Garland Pub. Inc., 2014.
GRIFFITHS, A. J. F. et al. Introdução à Genética. 9a ed. São Paulo: Guanabara-Koogan, 2008.
LEWIN, B. Genes VII. Porto Alegre: Editora Artmed, 2001.
STRACHAN, T.; READ, A. P. Genética molecular humana. 4 ed. Porto Alegre: Editora Artmed, 2013.
BROWN, T. A. Clonagem gênica e análise de DNA. 4 ed. Porto Alegre: Editora Artmed, 2003.
WATSON, J. D. et al. Biologia molecular do gene. 7.ed. Porto Alegre: Editora Artmed, 2015.

 

Special topics in physiology and homeostasis
Professor(s): Dra. Danúbia Frasson Furtado
Syllabus: Study of the general physiological principles from the core concept of homeostasis. Some subareas of physiology will be approached: the dynamics of functioning, function control and the integrative aspects of homeostatic maintenance.
Credit hours: 45 (forty-five) class hours
Credits: 03 (three)
Bibliography:
AIRES, M.M. Fisiologia. 3a. edição. Rio de Janeiro: Editora Guanabara Koogan, 2008.
GUYTON, A. C.; HALL, J. E. Tratado de fisiologia médica. 9a. edição. Rio de Janeiro: Editora Guanabara Koogan, 2011.
LEVY, M.N.; KOEPPEN, B.; STANTON, B.A. Fisiologia. 5a. edição. Rio de Janeiro: Elsevier Editora Ltda., 2009.
SCHMIDT-NIELSEN, K. Fisiologia animal: adaptação e meio ambiente, 5a. edição. São Paulo: Santos Livraria Editora, São Paulo, 2002.
TORTORA , G. J.; DERRICKSON, B. Princípios de anatomia e fisiologia. 12a. edição. Rio de Janeiro: Editora Guanabara Koogan, 2010.
WEST, John. Fisiologia respiratória. 6a. edição. Barueri: Editora Manole, 2002.

 

General and experimental toxicology
Professor(s): Dr. Cezar Rangel Pestana and Dr. Flávio Luiz Tavares
Syllabus: Principles of toxicology, exposure to substances of toxicological interest and the molecular mechanisms of intoxications, recognizing intoxications and preventing them, therapeutic, environmental and biological monitoring of exposure, epidemiology of intoxications, areas of toxicology, phases of intoxication and the main toxicological tests.
Credit hours: 45 (forty-five) class hours
Credits: 03 (three)
Bibliography:
GOODMAN, L.S. GILMAN, A.; BRUNTON, L.L. Goodman & Gilman's Manual of Pharmacology and Therapeutics. New York: McGraw-Hill Medical, 2008.
KATZUNG, B.G.; MASTERS, S.B.; TREVOR, A.J. Farmacologia básica e clínica (Lange). 12ª edição. New York: McGraw-Hill, 2013.
KLAASSEN, C.D.; CASARETT, L.J.; DOULL J. Casarett and Doull's Toxicology: the basic science of poisons. 8th edition. New York: McGraw-Hill Education, 2013.
KLAASSEN, C.D.; WATKINS, J.B. Casarett & Doull's Fundamentos em toxicologia. 2a. ed. New York: McGraw-Hill Professional, 2012.
OGA, S.; CAMARGO, M.M.A.; BATISTUZZO, J.A.O. Fundamentos de toxicologia. 3a. edição. Atheneu, 2008.